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Call for Paper - May – 2024 Edition   

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IJATCA solicits original research papers for the May – 2024 Edition.
Last date of manuscript submission is May 30, 2024.

                                                   

Analysis of Protein Structure based Drug Design Using Comparative Molecular Field Analysis


Volume: 4 Issue: 7
Year of Publication: 2017
Authors: Mrs. B.Kalaiselvi, Dr.M.Thangamani



Abstract

Proteins are molecular devices in the nanometer scale where biological function is exerted the building blocks of all cells in our bodies. DNA molecule is encoded in the dynamic process of life maintenance; replication, defense and reproduction are carried out by proteins. There are twenty natural amino acids whose frequency is higher and with the particular functions are forming polypeptide chains or proteins in different ways determined by the genetic code and limited by stereo chemical properties. Molecular Function is describes the tasks performed by individual proteins and can be broadly divided into twelve subcategories such as cellular processes, metabolism, DNA replication/modification, transcription/translation, intracellular signaling, cell-cell communication, protein folding/degradation, transport, multifunctional proteins, cytoskeletal/structural, defense and immunity, and miscellaneous functions. Biochemical reactions of cell breathing, oxygen and carbonic gas transport, food absorption, energy usage, energy storage, heat or cold physiological reactions, or any life process one can carry out by a protein or a protein complex. The primary structure of a protein referred to its complete covalent structure but it is more frequently interpreted as the sequence of amino acids of each polypeptide chain of which the protein is composed. All processes in a living organism have proteins are acting as the developed under the natural selection. All proteins functions are dependent on their structure which depends on physical and chemical parameters. The genome sequences make it more difficult to identify our target sequence to find the putative gene directly or DNA sequences containing the putative gene. The bioinformatics have been working together in a new area known as molecules, classical biological, physical, chemical, mathematical and informatics to allow a new level of knowledge about life organization.

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Keywords

Acid sequence, polypeptide chain, terminus, GenBank.




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